Well, isn't down's syndrome biologically unsustainable?
Didn't know. Had to look it up. Still not sure what the precise answer is. From this reference, best I could do is: Literally....no. Practically...pretty close.
http://www.ds-health.com/issues.htm
Significantly impaired fertility of both sexes is evident in the Down syndrome population (Rogers and Coleman, 1992). While males have long been assumed to be sterile, Sheridan reports one case of a cytogenetically normal male infant that was fathered by a man with Down syndrome (Sheridan et al, 1980). Women have impaired but still significant fertility: a number of reviews document women with Down syndrome carrying pregnancy to term and delivering infants with and without Down syndrome (Bovicelli et al, 1982; Rani et al, 1990). Infants born to mothers with Down syndrome are at increased risk for premature delivery and low birth weight (Bovicelli et al, 1982). Pregnancy outcomes obtained from a study of mothers with Down syndrome are displayed in Table 5. Whether a woman with Down syndrome constitutes a high risk pregnancy depends largely on cognitive level and medical status. Obviously, the presence of maternal cardiac, thyroid, or hepatic disease, as well as seizure disorder, complicates a pregnancy. The high incidence of congenital heart disease in any offspring with Down syndrome contributes to pregnancy risk, including stillbirth and neonatal death (Gordon, 1990). Offspring without Down syndrome have a greater than average number of congenital anomalies (Bovicelli et al 1982) (see Table 5).
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